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Safety Adverse effects -Linolenic acid (18:3n-6) Supplemental -linolenic acid is generally well tolerated, and serious adverse side effects have not been observed at doses up to 2.8 g/day for 12 months (209)

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Excess macronutrients in adipose tissues trigger the release of inflammatory mediators, including leptin, tumor necrosis factor-, and interleukin-6, while decreasing the production of adiponectin (an anti-inflammatory adipokine), predisposing to a pro-inflammatory state and oxidative stress

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